Thyroid Hormone and Patient Satisfaction

Journal of Clinical Endocrinology and Metabolism, May 2005

Patients preferred combined T4/T3 therapy to usual T4 therapy. Decrease in weight was associated with satisfaction with study medication.

Combined Therapy with levothyroxine (T4) and liothyronine (T3) compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized clinical trial. J Clin Endocrinol Metab. 2005 May;90(5):2666-74. Epub 2005 Feb 10.

European Journal of Endocrinology, 2009

A double blind, randomized cross-over study was done to compare the effect of combination therapy with T4 and T3 versus T4 monotherapy in patients with hypothyroidism already being treated with T4 alone. Conclusion: Treatment with high dose of T3 was superior to (T4) monotherapy by evaluating several quality of life, depression and anxiety rating scales as well as patients own preference.

Effect of combination therapy with thyroxine (T4) and triiodothyronine (T3) versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. Eur. J. Endocrinol., December 1, 2009; 161(6): 895 ? 902.